P. Ramu Sridhar
Professor
| Ph. D. | IISc Bangalore, 2004 |
| Postdoctoral Research | University of Illinois Chicago, 2004 - 2005 |
| Purdue University, 2005 - 2006 | |
| Ohio State University, 2006 - 2007 | |
| Assistant Professor | University of Hyderabad, 2007 - 2016 |
| Associate Professor |
University of Hyderabad, 2016 - 2020 |
| Professor | University of Hyderabad, 2020 - Present |
Phone: +91- 40- 23134823, E-mail: [email protected]
Research Interests
(1) Total synthesis of natural products. (2) Carbohydrate Chemistry. (3) Chemical biology
(4) Carbohydrate based drug design and discovery
The research group involves the total synthesis of natural products using carbohydrates as chiral pool starting materials. Synthesis of amino-acid and carbohydrate hybrids like glyco-amino acids and carbohydrate conjugates has also been investigated in our group. In addition, our research also focused on the development of straight forward synthetic methodologies for the construction crucial subunits, such as fused bicycles and spirocycles, which are present in various highly bio-active natural products possessing anti-inflammatory and anti-diabetic properties.
(4) Carbohydrate based drug design and discovery
The research group involves the total synthesis of natural products using carbohydrates as chiral pool starting materials. Synthesis of amino-acid and carbohydrate hybrids like glyco-amino acids and carbohydrate conjugates has also been investigated in our group. In addition, our research also focused on the development of straight forward synthetic methodologies for the construction crucial subunits, such as fused bicycles and spirocycles, which are present in various highly bio-active natural products possessing anti-inflammatory and anti-diabetic properties.
Selected Publications
- Stereoselective synthesis of 1,6-dioxaspirolactones from spiro-cyclopropanecarboxylated sugars: total synthesis of dihydro-pyrenolide D. Ramakrishna, B.; Srihdar, P. R. RSC Adv. 2015, 5, 8142.
- Stereoselective synthesis of C-2-methylene and C-2-methyl alfa- and beta-C-glycosides from 2-C-branched glycals: Formal total synthesis of (–)-brevisamide. Sudharani, C.; Venukumar, P.; and Sridhar, P. R. Eur. J. Org. Chem. 2014, 8085.
- First Stereoselective Total Synthesis of Neosemburin and Isoneosemburin. Reddy, G. M.; Sridhar, P. R. Sridhar. Org. Biomol. Chem. 2014, 12, 8408.
- A one-pot septanoside formation and glycosylation of acyclic dithioacetals derived from 1,2-cyclopropanated sugars. Venukumar, P.; Sudharani, C.; Sridhar, P. R. Chem. Commun. 2014, 50, 2218.
- Ring contraction vs ring-expansion reactions of spirocyclopropanecarboxylated sugars. Ramakrishna, B.; Sridhar, P. R. Org. Lett. 2013, 15, 4474.