R. Nagarajan
Professor
| Ph. D. | University of Madras (CLRI), 2003 |
| Postdoctoral Research | National Taiwan University, 2004 |
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National University of Singapore, 2004 - 2005 |
| Assistant Professor | University of Hyderabad, 2005 - 2012 |
| Associate Professor |
University of Hyderabad, 2012 - 2015 |
| Professor | University of Hyderabad, 2015 - Present |
Phone: +91- 40- 23134831, E-mail: [email protected]
Research Interests
Heterocyclic Chemistry - Total Synthesis of Alkaloids
Alkaloids contribute to an important class of natural products in organic chemistry. We have been working on synthesis of various
bioactive alkaloids in a concise route using new/novel methodologies. Our research group have reported the first total synthesis of
alkaloids (±)-Oxoaplysinopsin B, 7-Bromo-1-(6-bromo-1H-indol-3-yl)-9H-carbazole, Pseudellone C, Mansouramycin D,
Penicinoline E, Metagenetriindole C, Sannanine and Arsindoline A & B and synthetic methodology for Calothrixin A & B, Cruciferane,
Ellipticine, Actinophenanthroline A, Metatacarbolines, Lavendamycin, Eudistomin U, Scalaridine A and Bouchardatine.
Our current interest is metal-free methodologies for synthesis of alkaloids.
Alkaloids contribute to an important class of natural products in organic chemistry. We have been working on synthesis of various
bioactive alkaloids in a concise route using new/novel methodologies. Our research group have reported the first total synthesis of
alkaloids (±)-Oxoaplysinopsin B, 7-Bromo-1-(6-bromo-1H-indol-3-yl)-9H-carbazole, Pseudellone C, Mansouramycin D,
Penicinoline E, Metagenetriindole C, Sannanine and Arsindoline A & B and synthetic methodology for Calothrixin A & B, Cruciferane,
Ellipticine, Actinophenanthroline A, Metatacarbolines, Lavendamycin, Eudistomin U, Scalaridine A and Bouchardatine.
Our current interest is metal-free methodologies for synthesis of alkaloids.
Selected Publications
- P. P. Sathieshkumar, M. D. A. Saibabu and R. Nagarajan “A Cascade Approach for the Synthesis of 5-(Indol-3-yl)hydantoin: An Application to the Total Synthesis of (±)-Oxoaplysinopsin B” J. Org. Chem., 2021, 86, 3730-3740.
- G. Ranjani and R. Nagarajan “Access to 1-indolyltetrahydro-β-carbolines via metal-free cross-dehydrogenative coupling: the total synthesis of eudistomin U, isoeudistomin U and 19-bromoisoeudistomin U” Chem. Commun., 2021, 57, 757-760.
- G. Ranjani and R. Nagarajan “Metal‒Free C‒H Functionalization and Aromatization Sequence for the Synthesis of 1-(Indol-3-yl)carbazoles and Total Synthesis of 7-Bromo-1-(6-bromo-1H-indol-3-yl)-9H-carbazole” Org. Lett., 2019, 21, 675-678.
- G. Ranjani and R. Nagarajan, “Insight into Copper Catalysis: in situ formed Nano Cu2O in Suzuki‒Miyaura Cross Coupling of Aryl/ Indolyl Boronates” Org. Lett., 2017, 19, 3974-3977.
- P. P. Sathieshkumar, P. Latha and R. Nagarajan, ‟Total Synthesis of Pseudellone C” Eur. J. Org. Chem., 2017, 3161-3164.